Contraindications

Acomplia should not be taken, or should be taken only under exceptional circumstances under your doctor's direct guidance, in the following circumstances:

1. Anyone who exhibits hypersensitivity or an allergic reaction to the drug (it should never be used in these circumstances).
2. Anyone with an impaired liver function. The effects of Acomplia have not been studied in patients with liver damage.
3. Anyone with impaired kidney function. It should never be used in patients with a severly limited kidney function.
4. Anyone over the age of 75. There is no data currently available to establish safety in this age group.
5. Any children under the age of 18 - there is currently a lack of data on efficacy and safety for this age group.
6. Pregnant or lactating women - safety in these groups has not been established. Indeed, current data in rats shows possible damage to the developing foetus and an inhibited sucking reflex in young rats.
7. There is little data on the safety of Acomplia in patients suffering from epilepsy and it should be prescribed with caution in these instances.
8. The Acomplia tablet contains lactose and should therefore not be prescribed to patients with a lactose intolerance.
9. It should only be used with caution in combination with CYP3A4 inhibitors, such as ketocinazole, ritonavir, clarthromycin and related drugs.
10. It should not be prescribed to patients with an uncontrolled psychiatric condition, and is not recommended for use with antidepressants as there is a lack of data on the safety in these circumstances. Acomplia may bring about an increased incidence of "suicidal thoughts", or even suicide itself, and is contraindicated for patients who are clinically depressed or who are taking antidepressants.

We make no claims as to the completeness of this list - there may well be other contraindications to the prescription of Acomplia.

Further, more detailed information on contraindications can be found here.